JAK inhibitors attenuate hyperactivation of nonswitched memory B cells in rheumatoid arthritis patients in remission

Abstract Objective To investigate the distribution and activation of B-cell subpopulations in rheumatoid arthritis (RA) patients treated with Janus kinase inhibitors (JAKis) and to analyze their correlation with disease remission.Methods Peripheral blood samples were collected from 23 adult healthy controls and 58 RA patients, 31 of whom were treat

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Inescapable Media: The Role of Social Media Data Mining in Understanding American Adolescent Media Engagement

With social media as the frontier of many American adolescent lives, there seems to be a shift in experiences of the new generation.This paper delves into the impacts of American adolescent media engagement, with a priority of the role of social media data mining in understanding behaviour and trends.This study utilizes innovative data mining techn

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EDUCATION DURING THE ERA OF ECONOMY OF KNOWLEDGE

Features of modern Shorts economy as "economy of knowledge" are defined.The changes happening in education in the conditions of strengthening of a role of knowledge in economic life of society are considered.Tasks of modern universities in production of knowledge are characterized, connection of the state, LEVER universities and business is shown.T

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Fungal Stress Responses and the Importance of GPCRs

G-protein-coupled receptors (GPCRs) play a crucial role in the gene regulation of processes related to the response to different types of stress in fungi.These Soft Books receptors act as sensors of extracellular signals and transmit the information to the interior of the cell through G-proteins.In the presence of different and specific types of st

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Wildfire cause analysis: four case-studies in southern Italy

Forest fires in Italy are mainly caused by humans, and directly depend on social behavior, whether voluntary (arson) or involuntary (negligence).Despite the progress in knowledge made with studying the physical facets of the phenomenon, causes and motives of human-related fire remain mostly unknown.This paper proposes the implementation of the Delp

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